Last updated: 20/9/26 at 7am
AJ Brown has been placed on injured reserve and will miss at least four games.
De’Zhaun Stribling is expected to miss around 10 weeks after undergoing surgery on his injured ankle.
Ladd McConkey (ribs) returned to practice as a limited participant on Friday after missing Wednesday and Thursday. He is listed as questionable against the Raiders.
Nico Collins (hamstring) has been ruled out against the Bengals after missing practice on Thursday and Friday.
Zay Flowers (hamstring) has been ruled out against the Saints after initially being listed as doubtful.
Sam Darnold (glute) has been ruled out against the Cardinals, with Drew Lock set to start in his place.
Brock Bowers (knee) returned to practice on Friday but is listed as doubtful against the Chargers.
Malik Willis (toe) has continued to participate fully in practice and has no injury designation in Week 2.
Joe Burrow (back) returned to full practice on Friday and carries no injury designation into the game against the Texans.
Kyler Murray (concussion) has been ruled out against the Bears after failing to clear concussion protocol. Carson Wentz will start in his place.
Brian Thomas Jr. (shoulder) was limited during the week but carries no injury designation into the game against Denver.
RJ Harvey (hamstring) was limited on Thursday and Friday after missing Wednesday’s practice and is listed as questionable against the Jaguars.
Chig Okonkwo (hamstring) has been ruled out against the Cowboys after missing practice during the week.
Tua Tagovailoa (oblique) and Michael Penix Jr. (knee) are both expected to miss Week 2, leaving Cooper Rush likely to start against the Panthers.
D’Andre Swift (ankle/knee) and Kyle Monangai (hamstring) returned to full participation on Friday and carry no injury designation into the game against Minnesota.
Ja’Kobi Lane (wrist) has been placed on IR following surgery and will miss at least four games.
Chris Olave (hamstring) is listed as questionable against the Ravens after being added to the injury report on Thursday.
Alec Pierce (heel) was downgraded from a full participant on Wednesday to missing practice on Thursday.
Jalen Coker (ankle) returned to full participation on Friday after being limited on Wednesday and Thursday. He carries no injury designation into the game against Atlanta.
Puka Nacua (hip) did not participate in practice on Friday and is listed as questionable against the Giants. Sean McVay described the issue as groin soreness, with Nacua's availability still to be determined.
Michael Pittman Jr. (foot) has been ruled out against the Patriots after missing practice on Thursday and Friday.
Kaelon Black (groin) is listed as questionable against the Dolphins after sharing the 49ers' backfield with Christian McCaffrey in Week 1.
This article will be updated all the way through to Sunday, so continue checking back.